Yusuke Higashino
Japan
Research Article
Role of 3,5-Digalloyl and 3’,4’-Dihydroxyl Structure of (–)-Epicatechin-3,5-Digallate in Inhibition of Hela S3 Cell Proliferation
Author(s): Taichi Hojima, Shingo Komeda, Yusuke Higashino, Masahiro Hamada, Noriyuki Nakajima, Takashi Kawasaki and Akiko SaitoTaichi Hojima, Shingo Komeda, Yusuke Higashino, Masahiro Hamada, Noriyuki Nakajima, Takashi Kawasaki and Akiko Saito
Flavan-3-ol derivatives are common plant-derived bioactive compounds with strong various biological activities. In particular, (–)-epigallocatechin-3-O-gallate exhibits a variety of moderate biological activities without severe toxicity. Its health-promoting effects have been widely studied because it is a main ingredient in green tea and is commercially available at low cost. In general, the galloyl moieties of flavan-3-ol derivatives are thought to be essential to their strong biological activities. However, it is not clear which position is most effective for modification with the galloyl moiety to strengthen the biological activities because various galloylated analogs are difficult to obtain in pure form in a quantity large enough for assays. Therefore, we synthesized various galloylated flavan-3-ol derivatives in a stereoselective and regioselective manner. We reported in .. View More»
