Yu-Long Li
Omaha, NE 68198-5850
Tanzania
Research Article
Elevated Angiotensin II in Rat Nodose Ganglia Primes Diabetes-Blunted Arterial Baroreflex Sensitivity: Involvement of NADPH Oxidase Derived Superoxide
Author(s): Yu-Long LiYu-Long Li
Clinical trials and experimental animal studies have confirmed the contribution of arterial baroreflex impairment in causing excess morbidity and mortality in type-1 diabetes. Our previous study has shown that angiotensin II (Ang II)-NADPH oxidase-superoxide signaling is associated with the reduced cell excitability in the aortic baroreceptor neurons (a primary afferent limb of the arterial baroreflex) from diabetic rats. In this study, we examined whether above-mentioned signaling might contribute to the blunted baroreflex sensitivity in streptozotocin-induced diabetic rats. Using Ang II 125 I radioimmunoassay and lucigeninchemiluminescence method, we found Ang II concentration, NADPH oxidase activity, and superoxide production in the nodose ganglia were enhanced in diabetic rats, compared to sham rats.As an index of the arterial baroreflex sensitivity, the refle.. View More»
