Yoshihiko Yamaguchi
Japan
Research Article
Hypoglycemic Effects of Morus alba Leaf Extract on Postprandial Glucose and Insulin Levels in Patients with Type 2 Diabetes Treated with Sulfonylurea Hypoglycemic Agents
Author(s): Sadako Nakamura, Michiru Hashiguchi, Yoshihiko Yamaguchi and Tsuneyuki OkuSadako Nakamura, Michiru Hashiguchi, Yoshihiko Yamaguchi and Tsuneyuki Oku
Phytochemical extracts with α-glucosidase inhibitory activity are widely used in processed foods with hypoglycemic effect. However the interactions between these phytochemical extracts and prescribed medicines have not yet been investigated. The leaf extract of Morus alba (LEM) shows the competitive inhibition to α-glucosidase. This single- blinded, placebo-controlled study investigated the effects of LEM on postprandial glucose and insulin levels in type 2 diabetes patients treated with or without sulfonylurea hypoglycemic agents (SU). Blood was collected from patients and healthy subjects at the indicated times after the ingestion of jelly containing LEM. A hydrogen breath test was performed simultaneously in healthy subjects to detect undigested sucrose in the jelly, which is fermented by intestinal microbes to produce hydrogen. Postprandial elevations in .. View More»
