WeiLi Chai
China
Research Article
The Relationship between MMP-9 and Infarct Related Artery Reflow in Acute STEMI Patients
Author(s): WeiLi Chai, Meipin Liu, Meipin Liu, Chunbao Yu, WenBo Liu and Fangming GuoWeiLi Chai, Meipin Liu, Meipin Liu, Chunbao Yu, WenBo Liu and Fangming Guo
Objective: Atherosclerotic plaque rupture leading to coronary artery occlusion is the culprit event which underpins a majority of acute myocardial infarction, and Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix degradation and artificial balloon extrusion. Patients with ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture are at high risk for slow reflow, but the relationship between reflow and MMP-9 remains unclear, especially in the real world of local plaque rupture. We investigated the association between the levels of matrix metalloproteinase-9 (MMP-9) in infarct-related arterial infusion and the risk of slow reflow in STEMI patients following percutaneous coronary intervention (PCI).
Methods: 65 eligible acute STEMI patients undergoing successful .. View More»
