Weaver JU
United Kingdom
Research Article
Peripheral Bone Mineral Density and Bone Turnover in Postmenopausal Women with Type 2 Diabetes
Author(s): Saeed BO, Nixon SJ and Weaver JUSaeed BO, Nixon SJ and Weaver JU
Objective: Several studies have suggested that diabetes affects Bone Mineral Density (BMD). In this study, we investigated the effect of type 2 diabetes mellitus (T2DM) on BMD and the rate of bone turnover in postmenopausal women.
Methods: This is a cross-sectional study, in which we measured peripheral bone density and markers of bone turnover in 60 postmenopausal women with T2DM and 48 age, alcohol intake and physical activity - matched control postmenopausal women without diabetes.
Results: BMD was significantly greater in subjects with T2DM than controls (0.51 gm/cm2 vs. 0.47 gm/cm2, p<0.01). Women with T2DM also had higher Body Mass Index (BMI) than the control group (mean: 33.7 kg/m2 vs. 26.7 kg/m2, p<0.0001). The difference in BMD between the two groups became non-significant after adjusting for the effect of BMI by multiple regression analysis (p=0.09.. View More»
