Veenendaal MVE
Biostatistics and Bioinformatics, Academic Medical Center,
PO box 22660, 1100 DD Amsterdam
England
Review Article
Is the Fetal Origins Hypothesis of Diabetes Supported by Animal Research? A Systematic Review and Meta-Analysis of the Evidence
Author(s): Veenendaal MVE, Thangaratinam S, Yates D, Painter RC, de Rooij SR, van der Post JAM, PMM Bossuyt, Saade GR, Mol BWJ, Khan KS and Roseboom TJVeenendaal MVE, Thangaratinam S, Yates D, Painter RC, de Rooij SR, van der Post JAM, PMM Bossuyt, Saade GR, Mol BWJ, Khan KS and Roseboom TJ
The fetal programming hypothesis states that fetal undernutrition during pregnancy results in permanent changes in the offspring’s metabolism. A large number of animal studies have evaluated the effect of prenatal undernutrition on later glucose metabolism.
Aim: We systematically reviewed the existing animal literature examining effects of prenatal undernutrition on glucose and insulin metabolism.
Methods: An electronic search was performed in Medline and Embase to identify all articles that reported studies investigating the effect of prenatal undernutrition on plasma insulin, plasma glucose and beta cell mass in animal models. Summary estimates of the effect of prenatal undernutrition on mean glucose concentration, insulin level, and beta cell mass were obtained through meta-analysis.
Results: The search resulted in 1827 articles, of which 117 were pote.. View More»
