Umesh Kumar Singh
India
Research Article
Combination of PPAR-? Agonist and DPP-4 Inhibitor: A Novel Therapeutic Approach in the Management of Diabetic Nephropathy
Author(s): Mandeep Kumar Arora and Umesh Kumar SinghMandeep Kumar Arora and Umesh Kumar Singh
The present study investigated the combined effect of fenofibrate (PPAR-α agonist) and saxagliptin (DPP-4 inhibitor) in diabetes-induced experimental nephropathy. Rats were administered streptozotocin (STZ) (55 mg/ kg i.p., once) to induce experimental diabetes mellitus. The development of diabetic nephropathy was assessed biochemically and histologically. In addition, the diabetes-induced lipid profile and renal oxidative stress were assessed. The single administration of STZ produced diabetes, which induced renal oxidative stress, altered the lipid profile and subsequently produced nephropathy in 8 weeks by increasing serum creatinine, blood urea nitrogen, proteinuria, and glomerular damage. Treatment with fenofibrate (30 mg/kg/day p.o.) normalized the altered lipid profile in diabetic rats, whereas the saxagliptin (3 mg/kg p.o.) treatment has.. View More»
