Torbjörn Akerfeldt
Section of Anaesthesiology & Intensive Care,
Uppsala
Sweden
Research Article
Serum Leptin is Decreased Thirty Days after Surgery
Author(s): Torbjörn Akerfeldt, Miklos Lipcsey, Lena Gunningberg, Christine Leo Swenne and Anders LarssonTorbjörn Akerfeldt, Miklos Lipcsey, Lena Gunningberg, Christine Leo Swenne and Anders Larsson
Background: Leptin plays an important role for the regulation of food intake, energy expenditure and glucose control. The aim of this study was to study the effect of surgery on circulating levels of human leptin in a human elective surgery model.
Methods: A prospective observational study was conducted. Blood sampling was carried out prior to surgery and four and thirty days after elective surgery, respectively. Patients undergoing orthopedic surgery (n=29) and coronary bypass patients (n=21) were included in the study. Serum leptin levels were measured using sandwich ELISA. C-reactive protein (CRP) was analyzed by turbidimetry.
Results: Leptin values was significantly decreased thirty days after surgery in both orthopedic (p=0.002) and coronary bypass patients (p=0.003) in comparison with presurgical values. Conclusion.. View More»
