Tadasu Ikeda
School of Health Sciences, Faculty of Medicine,
Nishicho 86, Yonago 683-8503
Japan
Review Article
Long-Term Effect of Alendronate on Bone Mineral Density in Postmenopausal Type 2 Diabetes Mellitus
Author(s): Tadasu Ikeda and Keiko IwataTadasu Ikeda and Keiko Iwata
The purpose of this study was to investigate the long-term effect of anti-resorptive agent, alendronate, on bone mineral density (BMD) in postmenopausal osteoporotic diabetic women. Twelve postmenopausal type 2 diabetic women (mean age; 70.4 ± 5.4 yrs, duration of diabetes; 13.1 ± 3.9 yrs) were administered alendronate sodium (5 mg/day) for 5 years. The radial BMD and urinary N-telopeptide cross-linked collagen type (NTx), one of biochemical markers, were measured every year. These parameters were compared with those in age-matched 12 control postmenopausal diabetic women not treated with alendronate. The radial BMD significantly (p<0.05) decreased by 5.30% at 2yr, 8.38% at 3yr, 9.71% at 4yr, and 11.12% at 5yr, in control subjects. While, radial BMD did not significantly change in diabetic women treated with alendronate. The decrease in radial BMD was significantly gr.. View More»
