Suzanne M de la Monte
Pierre Galletti Research Building, Rhode Island Hospital,
55 Claverick Street, Room 419, Providence, RI 02903
Tanzania
Research Article
Motor Function Deficits Following Chronic Prenatal Ethanol Exposure are Linked to Impairments in Insulin/IGF, Notch and Wnt Signaling in the Cerebellum
Author(s): Ming Tong, Jason Ziplow, William Cy Chen, Quynh-Giao Nguyen, Charles Kim and Suzanne M de la MonteMing Tong, Jason Ziplow, William Cy Chen, Quynh-Giao Nguyen, Charles Kim and Suzanne M de la Monte
Background: Fetal alcohol spectrum disorder (FASD) is associated with deficits in cerebellar function that can persist through adolescence. Previous studies demonstrated striking inhibition of insulin and insulin-like growth factor (IGF) signaling in ethanol-exposed cerebella.
Objectives: We sought to determine if FASD-induced impairments in motor function were associated with deficits in insulin/IGF signaling in juvenile cerebella. Given the growing evidence that insulin/IGF pathways crosstalk with Notch and Wnt to promote brain development and maturation; we also examined the integrity of canonical Wnt and Notch signaling networks in the brain following chronic prenatal ethanol exposure.
Methods: Pregnant Long Evans rats were fed isocaloric liquid diets containing 0% or 24% ethanol by caloric content from gestation day 6 through delivery. Pups were subjected to rotar.. View More»
