Sudhakar A Yakkanti
Tanzania
Research Article
Influence of Piperine on Pioglitazone Metabolism and Pk/Pd: Diabetes Mellitus
Author(s): Prasad Neerati and Sudhakar A YakkantiPrasad Neerati and Sudhakar A Yakkanti
Background: Piperine is an alkaloidal compound and is an active constituent of black and long peppers. Piperine is known to inhibit cytochrome P- 450 isoforms. The objective was to determine the effects of dietary piperine on the pharmacokinetics and pharmacodynamics of pioglitazone.
Methods and Results: Set one non diabetic study, there are three groups, as 1,2 and 3 composed each of four Albino rabbits (2-3 kg). In the next set, another similar three groups named group 4 group 5 and group 6 were selected to investigate the influences in diabetic group after receiving alloxan monohydrate (80 mg/kg, i.v). Group 1 and group 2; group 4 and group 5 received pioglitazone (10 mg/kg; po) and piperine (20 mg/kg; po) respectively. Group 3 and group 6, we investigated herb drug interactions for single dose and multiple dose interactions on normal and diabetic rabbits.. View More»
