Stefanie J Willmann
Türkenstrasse 21, 80799 München,
Germany
Mini Review
Cutting the Edge of β-Cells – WNT Pathway Thrives Lineage Segregation in Pancreatic Organogenesis
Author(s): Stefanie J WillmannStefanie J Willmann
Lately Revealed by Genome-wide association studies (GWAS) the association of TCF7L2 and Type 2 Diabetes (T2D) which implicates underlying mechanism of this Wingless (WNT) pathway effector gene in pancreatic ß-cell development. Also, further research linking TCF7L2 to T2D and impaired ß-cell mass accomplished by insulin secretory malfunction, shed light on the regulatory function of this particular canonical WNT pathway member. Thus, highlighting the fact that indeed Dishevelled (DEL) regulates as a scaffold protein in canonical and non-canonical WNT regulatory pathway components. Fairly is understood in the process of canonical and non-canonical WNT signaling, except that DEL acts through transmembrane domains of co-/receptors as Frizzled (FZ) and Low-density lipoprotein receptor-related protein 5 (LRP5). Well described in the context of regulatory mechanism is the canonical.. View More»
