Sonia Rawal
Tanzania
Research Article
Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats
Author(s): Sonia Rawal, Han-Hung Huang, Lesya Novikova, Tyler Hamedi, Irina V Smirnova and Lisa Stehno-BittelSonia Rawal, Han-Hung Huang, Lesya Novikova, Tyler Hamedi, Irina V Smirnova and Lisa Stehno-Bittel
Exercise and physical activity improve the glycemic control in people with type 2 diabetes (T2D). It is known that activity improves muscle utilization of glucose, and that exercise can spare islets if initiated prior to the onset of diabetes. However, any effect of exercise on pancreatic islet function after the diagnosis of overt diabetes is unknown. The aim of the study was to investigate the effects of exercise training on pancreatic islets in a rodent model of overt T2D. 12-week old male Zucker Diabetic Fatty (ZDF) rats and control lean rats were divided into 4 groups: sedentary control exercised control, sedentary diabetic and exercised diabetic. Exercised rats were trained with moderate intensity running on a treadmill for 7 weeks. Assessment of plasma insulin levels, islet cell composition (relative proportion of α, β and δ cells), islet density, insulin conte.. View More»
