Shyam Aggarwal
India
Research Article
KDR Mutation: A High-Frequency Rare Mutation and its Correlation with other Somatic Mutations in Indian Colorectal Cancer Patients
Author(s): Mayank Jauhri, Vani Gupta, Yogender Shokeen, Sachin Minhas, Sunita Bhalla and Shyam AggarwalMayank Jauhri, Vani Gupta, Yogender Shokeen, Sachin Minhas, Sunita Bhalla and Shyam Aggarwal
Aim: This study aims to find out the frequency of KDR mutation in colorectal cancer patients and if any correlation exists between KDR mutation and demographical features or with other common and uncommon gene mutations occurring in colon cancer.
Methods: FFPE samples of 112 patients were analyzed using next generation sequencing.
Results: KDR gene was found to be mutated most frequently (19.6%). As compared to other uncommon gene mutations occurring among patients. 21/22 patients had the p.Q472H type of KDR mutation. It was significantly associated with mutations in PTEN (p=0.003), KRAS (p=0.026), APC (p=0.033), EGFR (p=0.036), NOTCH1 (p=0.029) and ERBB4 (p=0.008) mutations. More number of males (22.06%) harbored KDR mutations than the number of females (15.9%). A higher number of KDR mutations in Stage III (31%) .. View More»
