Shinjini Mitra
India
Research Article
Prophylactic Use of Fisetin in Thioglycollate-Induced Peritonitis in Mice
Author(s): Shinjini Mitra, Kaustab Mukherjee, Silpak Biswas and Ena Ray BanerjeeShinjini Mitra, Kaustab Mukherjee, Silpak Biswas and Ena Ray Banerjee
Infectious or non-infectious peritonitis leads to systemic inflammation due to violation of the peritoneum which is often fatal. Fisetin, a flavonol compound, exhibits a broad spectrum of biological activities including anti-oxidant, anti-inflammatory, anti-cancer and neuro-protective effects. It was used in a murine model of thioglycollate (TG)- induced aseptic peritonitis to investigate its anti- inflammatory effects, and on RAW macrophage cells. In this study, peritonitis was induced in C57BL/6J mice using thioglycollate, and anti-inflammatory effects of fisetin, was assessed prophylactically. In in vitro study, cells treated with inflammatory agents like bacterial lipopolysaccharide (LPS) and phorbol-12-myristate-13-acetate (PMA) lose their viability and proliferative capacity. Fisetin has been shown to prevent the loss of viability when given prophylactically. In in vivo model, t.. View More»
