Sanjay Kumar
India
Research Article
Reduced High Density Lipoprotein Concentration Modulates Increased Interleukin-10 and Decreased Interferon-Gamma in Visceral Leishmaniasis Patients
Author(s): Ranjeet K Paswan, Sanjiva Bimal, Anjali Kumari, Preeti Sinha, Preeti Sinha, Krishna Pandey, Sanjay Kumar, Rakesh B Verma, Pradeep Das and Chandra S LalRanjeet K Paswan, Sanjiva Bimal, Anjali Kumari, Preeti Sinha, Preeti Sinha, Krishna Pandey, Sanjay Kumar, Rakesh B Verma, Pradeep Das and Chandra S Lal
Visceral leishmaniasis (commonly called kala-azar) is an immune-compromised parasitic protozoan disease. Hypocholesterolemia is one of the major observations in visceral leishmaniasis. The aim of this study was to evaluate and correlate total cholesterol and lipoproteins with gamma-interferon, a protective cytokine and interleukin-10, a disease progressive cytokine in visceral leishmaniasis patients. We conducted correlation studies among lipid profile, interleukin-10 and gamma-interferon on visceral leishmaniasis patients (n = 34). Lipid profile was analyzed on chemistry analyzer according to standard procedure. Gamma-interferon and interleukin-10 were analyzed quantitatively and qualitatively by enzyme linked immunosorbent assay and Fluorescence activated cell sorter respectively (n = 34). The releasing ability of interleukin-10 and gamma-interferon was assayed by fluorescence activate.. View More»