Sakil Ahmed
India
Research Article
Changes in Erythrocyte Membrane in Type-Ii Diabetes Mellitus with and without Dyslipidemia
Author(s): Robby Kumar, Amar Nagesh Kumar and Sakil AhmedRobby Kumar, Amar Nagesh Kumar and Sakil Ahmed
Background: In Diabetes mellitus there is decreased number of pump units on the erythrocyte membrane, altered lipid – protein interaction, depleted membrane anionic charge and enzyme glycation and peroxidation which account for many abnormal complications.
Method: Diabetes subjects with and without dyslipidemia were selected along with healthy control then we correlate the changes in serum and erythrocyte membrane.
Result: The lipid composition of membrane is significantly increased with cholesterol:phospholipid ratio and Na + K + - ATPase of membrane was decreased when compared to control. Conclusion: Lipid composition disturbances along with increased hyperglycemia which causes glycation of enzymes and oxidative stress causes the decrease in activity of Na + K + -ATPase and other .. View More»
