S Wiltshire
United Kingdom
Review Article
Haematological Problems and their Solutions in ABO-Incompatible Renal Transplants
Author(s): C Gan, I MacPhee, P Andrews, S Wiltshire, M Morsy, S Heap and N KessarisC Gan, I MacPhee, P Andrews, S Wiltshire, M Morsy, S Heap and N Kessaris
We report on the haematological complications that we have encountered in implementing ABO-incompatible kidney transplantation, and the solutions we have used to overcome these.
We have performed 5 ABO-incompatible transplants with an immunosuppression protocol involving Rituximab, immunoadsorption, Tacrolimus, Mycophenolate Mofetil, and Prednisolone. Our protocol for blood product transfusion includes the use of high titer negative or washed red cells, high titer negative platelets or platelets in platelet suspension medium, and type AB fresh frozen plasma.
Two patients required 2 units of washed red cells each and one required 2 units of platelets in platelet suspension medium at the time of surgery. The other two patients did not require any blood products. One of these, had an episode of acute vascular rejection which was successfully treated. All grafts are cu.. View More»
