Roberto T Sudo
Brazil
Research Article
Novel Nicotinic Receptor Agonist Reduces Hyperalgesia and Allodynia of Neuropathic Pain in Diabetic Rats
Author(s): Roberto C Debom, Margarete M Trachez, Gisele Zapata Sudo, Jaqueline S da Silva, Kesley M Oliveira, Ariel L Garcia, Lidiane M Godoy, Ogari C Pacheco and Roberto T SudoRoberto C Debom, Margarete M Trachez, Gisele Zapata Sudo, Jaqueline S da Silva, Kesley M Oliveira, Ariel L Garcia, Lidiane M Godoy, Ogari C Pacheco and Roberto T Sudo
Diabetic Peripheral Neuropathic Pain (DPNP) has been attributed to abnormal glucose metabolism and oxidative stress. It is among the most common consequence of chronic diabetes and is treated with antiepileptic compounds, antidepressants, and opioids. However, many patients with DPNP experience lack of treatment efficacy and/or adverse secondary effects that impair quality of life. Here we report the identification of a novel agonist targeting neuronal nicotinic Acetylcholine Receptors (nAChRs) that may alleviate neuropathic pain. A new pyrazole analogue, Cris-104, has been observed to produce antinociceptive activity in acute and chronic pain models. In the present study, Cris-104 effects on thermal hyperalgesia and mechanical allodynia were evaluated in a rat DPNP model. Oral administration of Cris-104 (35 mg.kg-1.day-1 for 7 days) induced antinociception as evidenced by reductions .. View More»
