Ranjit Singh Padda
Canada
Mini Review
Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes?
Author(s): Ranjit Singh Padda, Yixuan Shi, Chao-Sheng Lo, Shao-Ling Zhang and John SD ChanRanjit Singh Padda, Yixuan Shi, Chao-Sheng Lo, Shao-Ling Zhang and John SD Chan
The renin-angiotensin system (RAS) plays a pivotal role in mammalian
homeostasis
physiology. The RAS can be delineated into a classical RAS (the pressor arm) including angiotensinogen (Agt), renin, angiotensin-converting enzyme (ACE), angiotensin II (Ang II) and angiotensin type 1 receptor (AT1R), and a counterbalancing novel RAS(the depressor arm) including Agt, renin, angiotensin-converting enzyme-2 (ACE-2), angiotensin-(1-7) (Ang 1-7) and Ang 1-7 receptor (or Mas receptor (MasR)). Hyperglycemia (diabetes) induces severe tissue oxidative stress, which stimulates the pressor arm of the renal RAS axis and leads to an increase in ACE/ACE-2 ratio, with excessive formation of Ang II. There is a growing body of evidence for beneficial effects of the depressor arm of RAS (ACE-2/Ang 1-7/MasR) axis in diabetes, hypertension and several other diseased conditions. Evidence .. View More»
