Prasad Neerati
University College of Pharmaceutical Sciences,
Warangal , AP
India
Research Article
Influence of Curcumin on Pioglitazone Metabolism and Pk/Pd: Diabetes Mellitus
Author(s): Prasad Neerati, Ravi Karan M and Jagat R KanwarPrasad Neerati, Ravi Karan M and Jagat R Kanwar
Background: Curcumin is the principal curcuminoid of the popular Indian spice ingredients commonly known as turmeric. Curcumin is reported to inhibit cytochrome P-450 (CYP) enzymes and its isozymes. As turmeric is being consumed every day in Indian spices, it is essential to determine the potential interaction with drugs metabolised by CYP3A4 system.
Methods and results: The study was conducted to determine the potential influence of curcumin on pharmacokinetics and pharmacodynamics of pioglitazone in normal and diabetic rat models. In first study, three groups (groups 1, 2 and 3; n=6) of rats were taken as non diabetic (normal) groups. Second study, three other groups: (groups 4, 5 and 6) were selected similarly to test the effects on diabetic group after receiving alloxan monohydrate (120 mg/kg). Group 1 and 2; group 4 and 5 received pioglitazone orally (10 mg/kg) and curcum.. View More»
