Peter Vestergaard
Aarhus University Hospital THG,
Tage Hansens Gade 2, DK-8000 Aarhus C
Denmark
Review Article
Diabetes and Bone
Author(s): Peter VestergaardPeter Vestergaard
Diabetes – both type 1 (T1D) and type 2 (T2D) has profound effects on the skeleton. Bone turnover is reduced, i.e. bone biopsies show a reduced bone formation with reduced mineralisation, and a reduced number of bone cells. Biochemical markers of bone turnover show a reduction in both formation and resoprtion. Bone mineral density (BMD) is reduced in T1D, whereas an increased BMD is seen in T2D. Despite this, an increased risk of hip fractures is seen in both T1D and T2D, the increase in risk of fractures being more pronounced in T1D than in T2D. This discrepancy between BMD and fracture risk along with evidence from animal studies of a reduced bone biomechanical competence in diabetes suggest that the bone tissue is weakened in patients with diabetes. This weakening may be related to glycation of collagen and formation of advanced glycation end-products (AGE), which together wi.. View More»
