Njeri L Kimani
School of Pure and Applied Sciences,
P.O. Box 43844-00100, Nairobi
Kenya
Research Article
Antidiabetic Activity of Administration of Aqueous Extract of Berberis holstii
Author(s): Njeri L Kimani, Njangiru IK, Eliud NM Njagi and George O OrindaNjeri L Kimani, Njangiru IK, Eliud NM Njagi and George O Orinda
Diabetes mellitus in Kenya is of public health concern since it causes significant mortality and complications that are long term. Though conventional drugs are used in the management of diabetes mellitus they are expensive, unavailable and also have numerous side effects. Berberis are medicinally important and are used for various purposes. Berberis holstii has traditionally been used in the management of diabetes; however, the efficacy of this herb needs to be evaluated scientifically. The study aimed at determining the in vivo antidiabetic effects of root extracts of Berberis holstii in alloxaninduced diabetic male mice. In this study, eight groups of animals with five mice each were used. The reductions in blood glucose relative to their initial values were determined after oral and intraperitoneal administration of 25, 48.4, 93.5, 180.9, and 350 mg/kg body weight. Standard hypogl.. View More»
