Musa Mabandla
South Africa
Research Article
The Application of Pectin-Insulin Patch on Streptozotocin-Induced Diabetic Rats: Implications in the Hippocampal Function
Author(s): Ntethelelo Sibiya and Musa MabandlaNtethelelo Sibiya and Musa Mabandla
Background: Diabetics are at high risk of developing dementia associated diseases compared to non-diabetics. The learning and memory impairments manifested in diabetes are attributed to sustained hyperglycemia. Insulin injections are beneficial in preventing and attenuating the progression of these impairments. However, undesirable effects associated with the current mode of administration remains a challenge. In this study, we evaluated the effects of pectin-insulin patch on learning and memory deficits in diabetic animals.
Methods: Pectin-insulin patches (20.0, 40.8 and 82.9 μg/kg) applied on the skin of streptozotocin-induced diabetic rats, thrice daily for 45 days. Learning and memory was assessed using the Morris water maze and the novel object recognition behavioural paradigms. Blood glucose, hippocampal mass, hippocampal insulin re.. View More»
