Michael Carrion
300 Cedar Street, New Haven, CT, 06510
Tanzania
Research Article
Identification of Differentially Expressed Genes in Pancreatic Regulatory T-Cell Survival
Author(s): Jake Carrion and Michael CarrionJake Carrion and Michael Carrion
Objective: Many current Diabetes treatments cause broad-based
immunodeficiency
, though future organspecific therapies may be developed by exploiting genotypic differences found in regulatory T cell (Treg) subpopulations. This study goaled to determine genes preferentially expressed in pancreatic Tregs relative to other Treg subpopulations, tissues, and immune cells to serve as targets in Diabetes therapy. Methods: Multi-step microarray analysis using GenePattern Software identified genes specific to pancreatic Tregs relative to Tregs in other tissues and to other immune-cell populations. Functional analysis of identified genes was performed using BioGrid and String Databases. Microarray datasets (n=2236) curated from the NCBI GEO database were processed (via RMA normalization, outlier-array exclusion, and global median transformation) to confirm the specificity of.. View More»
