Michael Benzinou
China
Research Article
Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney
Author(s): Sheng Guo, Wubin Qian, Fenglai Du, Bingdi Wang, Xiaoli Wang, Yupeng Fang, Xuan Chen, Michael Benzinou, Francine M. Gregoire, Michael Staup, Keefe Chng, Yaxiong Chen, Yong-Fu Xiao and Yi-Xin (Jim) WangSheng Guo, Wubin Qian, Fenglai Du, Bingdi Wang, Xiaoli Wang, Yupeng Fang, Xuan Chen, Michael Benzinou, Francine M. Gregoire, Michael Staup, Keefe Chng, Yaxiong Chen, Yong-Fu Xiao and Yi-Xin (Jim) Wang
Although Type 2 Diabetes Mellitus (T2DM) is well characterized Non-Human Primate (NHP), the phenotypes of diabetic nephropathy, and its molecular mechanisms are not well studied in NHPs. Diabetic nephropathy in cynomolgus macaques with spontaneous dysmetabolism (Pre-DM, n=19) and diabetes (DM, n=20) were compared with normal controls (N, n=11). There were 9 NHPs with albuminuria (>42 mg/day) in the DM (45%), only 1 in Pre-DM and none in N group. The renal function measured by estimated glomerular filtration rate (eGFR) was not significantly different among the 3 groups, indicating that these NHPs were in an early stage of renal disease. From these NHPs, 3 N, 3 Pre-DM without albuminuria and 6 DM with albuminuria were selected for transcriptome analysis of kidney biopsies. There were 95 differentially expressed genes (DEGs) detected amongst the 3 groups, of which, 75DEGs between the.. View More»
