Mayu Izuno
Japan
Research Article
Role of 2,3-cis Structure of (-)-Epicatechin-3,5-O-digallate in Inhibition of HeLa S3 Cell Proliferation
Author(s): Kazuki Mori, Yoshihiro Ayano, Yoshitomo Hamada, Taichi Hojima, Ryuta Tanaka, Yusuke Higashino, Mayu Izuno, Taisuke Okamoto, Takashi Kawasaki, Masahiro Hamada, Noriyuki Nakajima and Akiko SaitoKazuki Mori, Yoshihiro Ayano, Yoshitomo Hamada, Taichi Hojima, Ryuta Tanaka, Yusuke Higashino, Mayu Izuno, Taisuke Okamoto, Takashi Kawasaki, Masahiro Hamada, Noriyuki Nakajima and Akiko Saito
Flavan-3-ol, which is primarily found in tea, is able to inhibit the proliferation of the human cancer cell line HeLa S3; in this study, we investigate the importance of the 2,3-cis structure in this inhibition. We synthesized six (−)-epicatechin and (+)-catechin analogs modified with a galloyl moiety at either the 3-hydroxyl, 5-hydroxyl, or 3,5-dihydroxyl positions. We then investigated their biological activity, DPPH radical scavenging activity and inhibitory activity on HeLa S3 cell proliferation. Among the six compounds, (−)-epicatechin-3,5-O-digallate showed the strongest inhibitory activity on HeLa S3 cell proliferation, whereas (+)-catechin-3,5-O-digallate was not active. In addition, there is no relation among the cell proliferation inhibitory activity and DPPH radical scavenging activity. Furthermore non-specific .. View More»
