Matteo Serino
Institute of National Health and Medical Research (INSERM), Toulouse, France, University Paul Sabatier (UPS), Mixed Research Unit (UMR) 1220, Institute for Re,
CHU Purpan, Instead of Doctor Baylac, CS 60039, 31024 Toulouse Cedex 3
France
Review Article
MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?
Author(s): Matteo SerinoMatteo Serino
The identification of molecular factors bridging gut microbiota dysbiosis to alterations of host metabolism still remains a major goal in biomedical research. In fact, on one hand, there is a worldwide consensus about the systemic impact, from brain to liver, from heart to adipose tissue, of gut microbiota dysbiosis. On the other hand, beyond the microbial production of short chain fatty acids and their vast metabolic properties, little is known about the molecular mechanisms linking a change in the activity of gut microbes to a modification of host cell metabolism. In this context, microRNAs (also known as miRs) are promising molecules which could allow explaining how dysbiosis is converted into metabolic outcomes since: 1- miRs are pleiotropic regulators of gene expression, targeting multiple mRNAs at once; 2- miRs expression in specific organs such.. View More»
