Markus Stücker
Ruhr-University Bochum, D-44805 Bochum
Germany
Research Article
Surface Ultra-Structure and Size of Human Corneocytes from Upper Stratum Corneum Layers of Normal and Diabetic Subjects with Discussion of Cohesion Aspects
Author(s): Markus Stücker, Michael Licht and H Michael HeiseMarkus Stücker, Michael Licht and H Michael Heise
Background: During the final stage of differentiation of cornified squamous epithelia like the human skin epidermis, anucleated corneocytes are formed. Formation of the horny layer and its ongoing desquamation are fundamental processes leading to the formation of an efficient epidermal barrier. Materials and methods: For a better understanding of the desquamation process, the role of corneocyte surface ultra-structure has been investigated using a special preparation technique for scanning electron microscopy (SEM). Human morphologically different corneocytes from the stratum corneum of the fingertip, the thenar eminence (thick skin), and the wrist below the carpus (thin skin) of normal and diabetic subjects were obtained by adhesive tape stripping. Results: The inside surface structure of corneocytes from thick skin shows prominent nubs, which are broader and more extended than those.. View More»
