Mahgoub SE
Sudan
Research Article
In Vitro Antileishmanial Activity of Helianthus annuus and Pulicaria crispa (Asteraceae)
Author(s): Mohamed M, Ahmed MM, Elwaleed EH, Walaa SE and Mahgoub SEMohamed M, Ahmed MM, Elwaleed EH, Walaa SE and Mahgoub SE
Leishmaniasis which is a neglected tropical disease is a global health problem. The treatment options are limited. They are either toxic or expensive. This study was conducted to test some medicinal plants belonging to Asteraceae family against Leishmania donovani promastigotes. Five plants have been selected: Helianthus annuus leaves, Pulicaria crispa aerial parts, Geigeria alata aerial parts, Acanthospermum hispidum aerial parts and Sonchus oleraceus leaves. H. annuus and P. crispa petroleum ether and chloroform extracts showed significant antileishmanial activity at 50 μg/mL in the general screening test, whereas the other three plant extracts showed significant antileishmanial activity in only one solvent system. H. annuus and P. crispa were further tested at doses range of 50, 25, 12.5, 6.25 and 3.125 μg/mL. The IC50 for petroleum ether and chloroform extracts of H. annuus .. View More»
