Małgorzata Paprocka-Borowicz
Poland
Research Article
Connection between Heat Shock Proteins 60/65 and Diabetic Vascular Complications
Author(s): Maciej Rabczyński, Żanna Fiodorenko-Dumas, Rajmund Adamiec and Małgorzata Paprocka-BorowiczMaciej Rabczyński, Żanna Fiodorenko-Dumas, Rajmund Adamiec and Małgorzata Paprocka-Borowicz
Introduction: Diabetes mellitus, as a metabolic disease, is closely associated with the development of atherosclerosis lesions. The share of heat shock proteins and antibodies in the HSP -60/65 atherogenesis in patients with type 2 diabetes is still an area subject to numerous studies.
Material and methods: The study was conducted in the group of 46 patients with type 2 diabetes mellitus with macrovascular complications and 62 patients with atherosclerosis. The control group was comprised of a cohort of healthy volunteers in the corresponding age. Tissue material acquired during the planned endarterectomy from the internal carotid artery was used to measure the serum levels of anti HSP 60/65, the plasma levels of vWF, and to perform the immunohistochemistry study.
Results: There was a higher concentration of anti HSP-60/65 in the group of patients with type 2 diabetes .. View More»
