M Kniotek
Poland
Research Article
Evaluation of Interferon-Gamma in Patients with Type 2 Diabetes and Colorectal Cancer
Author(s): I Bosek, R Kuczerowski, T Milek, A Sulich, B Kaleta, M Kniotek and P PiatkiewiczI Bosek, R Kuczerowski, T Milek, A Sulich, B Kaleta, M Kniotek and P Piatkiewicz
Introduction and objectives: Multiple studies suggest a common coexistence of type 2 diabetes mellitus (T2DM) and cancer, especially colorectal cancer (CC). One of the most important mechanism that may have an impact on the increased incidence of cancer in diabetes is deregulation in the immune system. Interferon gamma (IFNγ), a cytokine critical for anti-tumor immunity, enhances cytotoxic activity of Tc lymphocytes, natural killer (NK) cells, activates macrophages, affects the apoptosis and induces the production of other cytokines such as IL-2, IL-6. The aim of this study was to evaluate the concentration of IFNγ in patients with T2DM with accompanying colorectal cancer compared to patients with T2DM or colorectal cancer separately. Materials and methods: This study was performed in Department of Internal Diseases, Diabetology and Endocr.. View More»
