Letaief Afef
Laboratory of Biochemistry of faculty of medecine Sousse,
Tunisia
Research Article
Association of a 27-Bp Repeat Polymorphism in Intron 4 of Endothelial Constitutive Nitric Oxide Synthase Gene with Coronary Artery Disease in a Tunisian Population
Author(s): Letaief Afef, Benothmane Leila, Charfeddine Bassem, Ennez Hajri Samia, Guider Jridi and Limem KhalifaLetaief Afef, Benothmane Leila, Charfeddine Bassem, Ennez Hajri Samia, Guider Jridi and Limem Khalifa
Background: Nitric oxide (NO) plays a major role in the regulation of vascular tone associations between NO genotypes. Coronary artery disease (CAD) and other risk factors have been described by many authors. The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) gene intron 4a/b variable number of tandem repeats (VNTR) polymorphism and other risk factors in the developement of CAD in subjects of the Tunisian population.
Method: A total of 274 Tunisian patients with CAD and 162 healthy controls were included in the study. The eNOS gene inton 4a4b variable number of tandem repeats polymorphism was analysed by PCR. The plasma lipid levels and other risk factors were also determined in all subjects.
Results: A significant differences in genotype distribution and allele frequency .. View More»
