Khalid Abdul Kadir
Malaysia
Research Article
Low-dose Insulin Treatment Ameliorate Glucose Metabolism in Type 1 Diabetic Rats
Author(s): Athena Xin Hui Ng, So Ha Ton and Khalid Abdul KadirAthena Xin Hui Ng, So Ha Ton and Khalid Abdul Kadir
Study background: Type 1 diabetes is an insulin-dependent diabetes mellitus (IDDM) because the body does not produce sufficient insulin for daily need. Persistent high glucose level in the blood circulation can stimulate the advanced glycation end products/receptor for AGEs (AGE/RAGE) pathway leading to diabetic complications. Currently, there is no preventive measure for IDMM with only treatment focusing on delaying the onset of diabetic complications. This study aimed to investigate how the different insulin regimens given affect the glycemic control and glucose metabolism in type 1 diabetes. The effects on the AGE/RAGE axis were determined as well. Methods: Twenty-one male Sprague-Dawley rats were randomly assigned into three groups (Group A: streptozotocin-induced diabetic rats given high-dose insulin [5-7U per day], Group B: streptozotocin-induce.. View More»
