Khaled A. Abdel-Sater
Egypt
Research Article
Beneficial Effects of Calcium Channel Blocker “Nifedipine” on Abnormalities of Platelets and Lipid Metabolism in Patients with Type II Diabetes Mellitus
Author(s): El-Sayed Emara and Khaled A. Abdel-SaterEl-Sayed Emara and Khaled A. Abdel-Sater
Background and Aim: Platelets play a role in the microvascular as well as macrovascular complications of diabetic patients with serious implications in the pathogenesis of vascular disease in patients with type 2 diabetes. Hyperglycemia changes platelet functions by impairing calcium homeostasis. So, it is important to study the effect of nifedipine on platelet functions and cardiovascular complications associated with diabetes.
Methods: There were 3 groups, i.e. healthy non diabetics (control), type 2 diabetics, and type 2 diabetics with nifedipine therapy (20 in each). For all, the following measurements were done: the cytoplasmic free Ca 2+ concentration, platelet aggregation, lipid profiles, arterial blood pressure and heart rate.
Results: Using nifedipine sig.. View More»
