Junya Kuroda
Japan
Case Report
Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia
Author(s): Yoshiko (Fujimoto) Hirakawa, Kyoko (Taniguchi) Yoshihara, Hiroto Kaneko, Hitoji Uchiyama, Junya Kuroda and Masafumi TaniwakiYoshiko (Fujimoto) Hirakawa, Kyoko (Taniguchi) Yoshihara, Hiroto Kaneko, Hitoji Uchiyama, Junya Kuroda and Masafumi Taniwaki
Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. FasL is undetectable in the serum of healthy person, whereas it is high in that from patients with T-large granular lymphocytic leukemia and natural killer (NK) cell lymphoma. We experienced a case of aggressive NK cell leukemia presenting severe bone marrow necrosis (BMN) after administrating granulocyte colony stimulating factor (G-CSF). In concern with a relation to cytokine, his serum FasL was examined and found to be extremely elevated. Administration of G-CSF under a large quantity of soluble FasL might play an important role in the pathogenesis of BMN through apoptosis of hematopoietic cel.. View More»
