Jill D. Jacobson
Children’s Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine,
2401 Gillham Road, Kansas City, MO
Tanzania
Research Article
Biochemical Evidence for Reduced Carnitine Palmitoyl Transferase 1(CPT-1) Activity in Type 1 Diabetes Mellitus
Author(s): Jill D. Jacobson, L. Kurt Midyett, Uttam Garg, Ashley K. Sherman and Chetan PatelJill D. Jacobson, L. Kurt Midyett, Uttam Garg, Ashley K. Sherman and Chetan Patel
Background: Type 1 diabetes mellitus is reportedly characterized by deficiencies of plasma total and free carnitine. Several inherited defects in fatty acid oxidation are associated with carnitine deficiency and with recurrent hypoglycemia. Hypoglycemia continues to be the major limiting factor in the management of type 1 diabetes. Herein, we sought to identify a subset of patients with abnormalities in carnitine profiles. Associations between carnitine abnormalities and glycemic control were also sought.
Methods: We performed a single center, prospective, observational study including 153 type 1 diabetic participants and 21 healthy control participants. We measured total, free, and acylcarnitine levels by high performance liquid chromatography-mass spectrometry. Glucose measurements were downloaded from pa.. View More»
