Ibrahim S
Nigeria
Research Article
Anti-Peroxidative, Protective and Ameliorative Properties of Methanol Extract of All Parts of Morinda Lucida Benth in CCl4-Induced Liver Injury
Author(s): Adejo GO, Atawodi SE, Ameh DA and Ibrahim SAdejo GO, Atawodi SE, Ameh DA and Ibrahim S
The methanol extracts of all the various parts of Morinda lucida were studied in vivo for anti-peroxidative, protective and ameliorative effects against carbon tetrachloride (CCl4) induced hepatocellular injury. Thiobarbituric acid reactive substances (TBARS) concentration taken as a measure of lipid peroxidation showed pre-treatment with the parts each (100 mg/kg) conferring anti-peroxidative effect while the leaf and bark extracts showed anti-peroxidative effect in the post-treatment test. Markers of hepatic damage viz: AST, ALT, total and conjugated bilirubin also showed significant protection and amelioration against CCl4-induced liver damage. Lipid profile studies like TG, TC, LDL and HDL showed no statistical difference among the pre-treatment groups and the ‘normal control’ except in the ‘Root+CCl4’ or ‘Leaf+CCl4’.. View More»
