Hye-Jin Kim
Republic of Korea
Research Article
Mixture of Ethanol Extract of Grape Pomade and Omija Fruit Prevents Hyperglycemia and Alleviates Oxidative Stress in Mice Fed an Obesogenic Diet
Author(s): Su-Jung Cho, Un Ju Jung, Hye-Jin Kim, Ye Jin Kim, Youngji Han, Byoung Seok Moon, Yong Bok Park and Myoung-Sook ChoiSu-Jung Cho, Un Ju Jung, Hye-Jin Kim, Ye Jin Kim, Youngji Han, Byoung Seok Moon, Yong Bok Park and Myoung-Sook Choi
Background: A high-fat diet (HFD) is thought to be one of the main environmental factors for obesity in which oxidative stress is an important pathogenic mechanism of obesity-associated metabolic syndrome including diabetes. Polyphenol-rich food plants are known to improve obesity-related diseases. The aim of this study was to investigate the effects of grape pomace (GP) and GP plus omija fruit (GPOF) on hyperglycemia and oxidative stress in diet-induced obese (DIO) mice. Methods: Male C57BL/6J mice were fed an HFD with GP (0.5%, w/w) or GPOF (0.5% GP plus 0.05% omija fruit, w/w) for 12 weeks. One gram of GP contains 0.26 mg of total flavonoid and 0.475 mg of total polyphenol, while 1 g of GPOF contains 0.2635 mg of total flavonoid and 0.491 mg of total polyphenol. Results: GP and GPOF significantly lowered fasting blood glucose level and insulin/glucagon ratio compar.. View More»
