Harley BK
Faculty of Pharmacy and Pharmaceutical Sciences College of Health Sciences,
Kumasi Ashanti Region
Ghana
Research Article
Antioxidant, Glucose Uptake Stimulatory, α-Glucosidase and α-Amylase Inhibitory Effects of Myrianthus arboreus Stem Bark
Author(s): Harley BK, Dickson RA and Fleischer TCHarley BK, Dickson RA and Fleischer TC
Myrianthus arboreus is used traditionally in the management of diabetes in Ghana. The study seeks to evaluatethe antioxidant, glucose uptake, α-glucosidase and α-amylase inhibitory activities of the stem bark to support its folkloric use. The ethanol stem bark extract of M. arboreus was partitioned successively with petroleum ether, chloroform, ethyl acetate and n-butanol. The extract and fractions were evaluated for their glucose uptake effects in C2C12 myotubes and 3T3-L1 adipocytes. Their inhibitory action on α-glucosidase and α-amylase were also investigated whereas their antioxidant activities were evaluated using the DPPH and nitric oxide scavenging assays. The crude extract was further evaluated for its phenolic content, antioxidant capacity and reducing power. The stem bark extract significantly (P<0.05) stimulated glucose uptake in C2C12 myotubes an.. View More»
