Gary Adams
Insulin Diabetes Experimental Research Group, Faculty of Medicine and Health Sciences,
Nottingham , NG7 2UH
Review Article
The Therapeutic Role of C-peptide in the Amelioration of Type 1 Diabetes Associated Microvascular Dysfunction of the Kidneys and Nerves
Author(s): Gary Adams, Susannah Champion, Gemma Figg and Alex JervisGary Adams, Susannah Champion, Gemma Figg and Alex Jervis
Proinsulin C-peptide is biologically active and exerts a protective physiological role in Type 1 Diabetes mellitus. We evaluated the effect of C-peptide replacement on the renal and nerve function of patients with T1DM and attempted to determine the mechanism by which it may exert its effects. An electronic search for randomised control trials was carried out in the following databases; Pubmed, EMBASE, Medline, CINAHL, CENTRAL and Proquest. The primary results from included trials were statistically combined in a meta-analysis. Six (6) randomised control trials met the inclusion criteria. Two (2) investigated the effects of C-peptide on kidney function. Three (3) investigated the effects of C-peptide on nerve function. One (1) randomised control trial investigated the effect of C-peptide on both kidney and nerve function. C-peptide was found to exert .. View More»
