Gaëlle Gusto
France
Research Article
Body Mass Index, Fatty Liver Index and Other Metabolic Disturbances Differentially Affect Albuminuria and Glomerular Filtration Rate in the General Population
Author(s): Adrien Bigot, Gaëlle Gusto, Nane Copin, Bénédicte Sautenet, Olivier Lantieri and Jean-Michel HalimiAdrien Bigot, Gaëlle Gusto, Nane Copin, Bénédicte Sautenet, Olivier Lantieri and Jean-Michel Halimi
Objective: Obesity and diabetes mellitus increase the risk of chronic renal disease. However, whether body mass index (BMI) and metabolic disturbances are associated with renal dysfunction and affect similarly albuminuria and estimated glomerular filtration rate (eGFR) are less clear. Hence, the aim of this study was to describe these associations in the general French population.
Methods: We realised a large cross-sectional study of 118,314 subjects aged ≥ 40 years undergoing a medical examination in 11 French regional health centers. Results: Renal dysfunction ((abnormal albuminuria (≥ 30 mg/g) and/or low eGFR (<60 ml/min/1.73m2)) was observed in 5.3% of subjects. There was a J-curve relationship between BMI and the risk of abnormal albuminuria: underweight (BMI<18.5 kg/m²: odds ratio: 2.12 [95% confidence interval: 1.55-2.. View More»
