Research Article
Screening Indian Medicinal Plants to Control Diabetes – An In silico and In vitro Approach
Author(s): Fazeela Mehaboob Begum SM, Zakia Fathima S, Priya S, Sundararajan R and Hemalatha SFazeela Mehaboob Begum SM, Zakia Fathima S, Priya S, Sundararajan R and Hemalatha S
Aim: The goal of this study is to analyze the compounds with high binding affinity to Peroxisome Proliferator- Activated Receptor Gamma (PPARγ) by molecular docking and analyze the resulting medicinal plant by in vitro analysis.
Background: Diabetes Mellitus is a multifactorial disease leading to the several complications and thus, demanding for a therapeutic approach. Medicinal plants with several anti-diabetic compounds play an important role in treating diabetes. In this study, we report twenty eight compounds from fifteen Indian medicinal plants by targeting PPARγ, using an in silico approach. PPARγ is involved in adipocyte differentiation, glucose homeostasis, lipid storage and also improve insulin sensitivity and glucose tolerance and thus, helping in the treatment of diabetes. The goal of this study is to analyze the.. View More»
