Ena Ray Banerjee
35, Ballygunge Circular Road, Kolkata- 700019, West Bengal
India
Research Article
Specific Spatio-Temporal Interplay of Cell Movement defines Asthma Pathogenesis
Author(s): Ena Ray BanerjeeEna Ray Banerjee
Background: Inflammation and degeneration are the two edged swords that impale a pulmonary system with the maladies like asthma and idiopathic pulmonary fibrosis. To explore critical role players that orchestrate the etiology and pathogenesis of these diseases, we used various lung disease models in mice in specific genetic knockout templates. Materials and methods: Acute and chronic allergic asthma and idiopathic pulmonary fibrosis models in mouse were developed in various genetic knockout templates, namely α4Δ/ Δ (α41-/-), β2-/-, and α4-/- β2 mice, and the following parameters were measured to assess development of composite asthma phenotype- (i) airway hyper responsiveness to methacholine by measuring lung resistance and compliance by invasive, and Penh by non-invasive, plethysmography (ii) in situ inflammation status in lung parenchyma and l.. View More»
