Eman S Abdel-Reheim
Egypt
Research Article
Fatty-Sucrosed Diet/Minimal Dose of Streptozotocin-Treated Rat: A Novel Model of Gestational Diabetes Mellitus, Metabolic and Inflammatory Insight
Author(s): Eman S Abdel-Reheim, Adel Abd-Elmoneim A and Ahmed A HosniEman S Abdel-Reheim, Adel Abd-Elmoneim A and Ahmed A Hosni
To date, a variety of experiments were done to get animal models of diabetes types. The current study is a trial to get a Gestational Diabetes Mellitus (GDM) model which is comparable to that in human, using a minimal dose of Streptozotocin (STZ). Female albino rats were divided into two groups; one fed Normal Diet (ND) and the other fed Fatty-Sucrosed Diet (FSD) from 60 days of age onward. After five weeks on the diets (pregestational period), rats were mated and STZ (25 mg/kg b.wt.) was injected intraperitoneally to FSD-fed dams at the 7th day of gestation. During pregestational period, FSD-fed rats exhibited significant increase in body weight that reduced significantly after STZ injection in comparable to ND-fed rats. Frank hyperglycemia with mild decrease in serum insulin level of Gestational Diabetic (GD) dams showed a state of insulin resistance that clarified by the increase i.. View More»
