Dharambir K Sanghera
Section of Genetics,
940 Stanton L. Young Blvd., Rm. D317 BMSB, Oklahoma City, OK 73104
Tanzania
Research Article
Vitamin D Deficiency and Cardio-Metabolic Risk in a North Indian Community with Highly Prevalent Type 2 Diabetes
Author(s): Timothy R Braun, Latonya F Been, Piers R Blackett and Dharambir K SangheraTimothy R Braun, Latonya F Been, Piers R Blackett and Dharambir K Sanghera
Objective: The purpose of this investigation was to examine serum vitamin D status in a population of Punjabi ancestry from Northern India with a high prevalence of type 2 diabetes (T2D) and evaluate the effects of 25(OH)D levels on cardio-metabolic traits.
Research design and methods: We assessed cardiovascular risk factors and 25(OH)D levels in 1,765
participants (887 T2D cases, 878 normoglycemic controls).
Results: 76% of individuals were deficient (<50 nmol/L) in vitamin D. A higher percentage of T2D participants(83%) were vitamin D deficient compared to normoglycemic controls (68%)(p<0.0001).The prevalence of vitamin D deficiency increased progressively with body mass index (BMI) categories (p<0.0001): BMI<23 kg/m2, 65%; BMI 23-27.5 kg/m2, 75%; and BMI>27.5 kg/m2, 81%. T2D participants had significantly decreased serum 25(OH)D levels (β=-0.. View More»
