Coirini H
Laboratorio de Neurobiología, Instituto de Biología y Medicina Experimental (IBYME-CONICET),
Vuelta de Obligado 2490, (C1428ADN), Ciudad Autónoma de Buenos Aires
Argentina
Research Article
Synthetic Epoxy-Pregnan Steroids: Effects on Anxiety Behavior in Rats
Author(s): Rey M, Ghini AA and Coirini HRey M, Ghini AA and Coirini H
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like antidepressant and anxiolyticts, in a similar way to benzodiazepines. However, their rapid metabolism is a great disadvantage for medicinal treatments consideration. Synthetic steroid analogues with more bioavailability and stability arise like a solution to overcome these limitations. In previous studies, we evaluated the performance of a synthetic steroid group (Epoxies, similar to allopregnanolone and pregnanolone) throughout different assays in rat cerebral cortex and hippocampus, including neuroprotection and GABAA receptor modulation obtaining promising results. Taking into a.. View More»
