Clement YN
Trinidad and Tobago
Research Article
Leonotis nepetifolia Protects against Acetaminophen-Induced Hepatotoxicity: Histological Studies and the Role of Antioxidant Enzymes
Author(s): Williams AF, Clement YN, Nayak SB and Rao AVCWilliams AF, Clement YN, Nayak SB and Rao AVC
Aim of the study: High dose acetaminophen (APAP) increases the risk of liver injury caused by oxidative stress due to accumulation of reactive species. Although N-acetyl cysteine is the standard antidote used to treat acute APAPinduced liver failure, we proposed that known antioxidant phytochemicals in Leonotis nepetifolia extracts would protect against APAP-induced hepatic injury by modulating the activities of antioxidant enzymes. Materials and methods: Methanol and aqueous extracts of L. nepetifolia were orally administered in doses ranging (250 mg/kg to 1000 mg/kg) as pre- and post-treatment with high dose APAP (550 mg/kg) to Swiss albino mice. Twenty-four hours after the final dose, animals were euthanized and blood and liver collected for liver enzymes (ALT and AST), histological assessment and antioxidant enzyme assays. Results: Methanol and aq.. View More»
