Christodoulos Stefanadis
Greece
Research Article
Genetic Variant of the C-reactive Protein Gene and Prevalence of Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus
Author(s): Stavroula Papaoikonomou, Dimitris Tousoulis, Nicholas Tentolouris, Nikolaos Papageorgiou, Antigoni Miliou, Emmanuel Androulakis, Charalambos Antoniades and Christodoulos StefanadisStavroula Papaoikonomou, Dimitris Tousoulis, Nicholas Tentolouris, Nikolaos Papageorgiou, Antigoni Miliou, Emmanuel Androulakis, Charalambos Antoniades and Christodoulos Stefanadis
Objective: Diabetes mellitus is strongly associated with inflammatory procedures, obesity and macrovascular complications, while genetic factors are involved in the disease pathogenesis and its complications. The aim of this study was to examine the impact of A3872G polymorphism on C-reactive protein (CRP) gene on the prevalence of peripheral arterial disease (PAD) in Greek Caucasian subjects with type 2 diabetes mellitus (T2DM).
Methods: The study population consisted of 423 patients with T2DM. The A3872G polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme digestion (HpyCH4III). High sensitivity CRP was assayed by particle-enhanced immunonephelometry. PAD was diagnosed using clinical or ultrasonography criteria and/or ankle brachial index <0.9.
Results: The genot.. View More»
