Chong Shen
Indiana
Research Article
A Polymorphic Microdeletion in the RGS9 Gene Suppresses PTB Binding and Associates with Obesity
Author(s): Chong Shen, Meenakshi Sharma, Daniel C Reid, Pengtao Li, Jeremy Celver, Norhashimah Abu Seman, Jinfeng Chen, Senthil K Vasan, Hairu Wang, Tianwei Gu, Ying Liu, Wan Nazaimoon Wan Mohamud, Hongbing Shen, Kerstin Brismar, William G Fairbrother, Abraham Kovoor and Harvest F GuChong Shen, Meenakshi Sharma, Daniel C Reid, Pengtao Li, Jeremy Celver, Norhashimah Abu Seman, Jinfeng Chen, Senthil K Vasan, Hairu Wang, Tianwei Gu, Ying Liu, Wan Nazaimoon Wan Mohamud, Hongbing Shen, Kerstin Brismar, William G Fairbrother, Abraham Kovoor and Harvest F Gu
Objective: RGS9 is a member of the family of Regulators of G-Protein Signaling (RGS) proteins defined by the presence of an RGS domain which can accelerate the GTPase-activity of G protein Gα subunits. An insertion/deletion (I/D) polymorphism of the nucleotide sequence TTTCT (rs3215227) has been identified in the human RGS9 gene, which matches the consensus high affinity binding motif for the ubiquitously expressed RNA binding Polypyrimidine Tract Binding Protein (PTB). In this study, we evaluate the genetic association and functional relevance of this polymorphism in type 2 diabetes and obesity.
Subjects and methods: We genotyped a larger population of 9272 Chinese and Malaysian individuals for the RGS9 I/D polymorphism using Taq Man allelic discrimination protocols. We found that the D allele of the RGS9 polymorphism was associated w.. View More»
